Diagnosis of male infertility has mainly been based on the World Health Organization WHO manual-based semen parameter's concentration, motility and morphology. It has, however, become apparent that none of these parameters are reliable markers for evaluation of the fertility potential of a couple. A search for better markers has led to an increased focus on sperm chromatin integrity testing in fertility work-up and assisted reproductive techniques. During the last couple of decades, numerous sperm DNA integrity tests have been developed.
J Androl. Jan-Feb;24(1) The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation. Fernández JL( 1). Sperm Chromatin Dispersion Test before Sperm Preparation Is Predictive of Clinical Pregnancy in Cases of Unexplained Infertility Treated with Intrauterine.
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